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4 Protektive Medikamente (Organprotektoren): Literatur

Autor/en: J. Büntzel, F. Bruns, D. Lüftner, D. Pollmann, S. Schildhauer
Letzte Änderung: 25.01.2006
  • Antonadou D, Coliarakis N, Synodinou M, Athanassiou H, Konveli A, Verigos C, Georgakopoulos G, Panoussaki K, Karageorgis P, Throuvalas N.
    Clinical Radiation Oncology Hellenic Group: Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer.
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    A pharmacoeconomic evaluation of the use of dexrazoxane in preventing anthracycline-induced cardiotoxicity in patients with stage IIIB or IV metastatic breast cancer.
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  • Bohuslavizki KH, Klutmann S, Brenner W, Mester J, Hentze E, Claussen M.
    Salivary gland protection by amifostine in high-dose radioiodine therapy: results of a double-blind placebo-controlled study.
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  • Brizel DM, Wasserman TH, Henke M, Strnad V, Rudat V, Monnier A, Eschwege F, Zhang J, Russell L, Oster W, Sauer R.
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  • Büntzel J, Küttner K, Fröhlich D, Glatzel M.
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  • Büntzel J, Micke O, Glatzel M.
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  • Fukuoka M, Negoro S, Masuda N, Furuse K, Kawahara M, Kodama N, Ikegami H, Nakamura S, Nishio H, Ohnoshi T.
    Placebo-controlled double-blind comparative study on the preventive efficacy of mesna against ifosfamid-induced urinary disorders.
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  • Gelmon K, Eisenhauer E, Bryce C, Tolcher A, Mayer L, Tomlinson E, Zee B, Blackstein M, Tomiak E, Yan J, Batist G, Fisher B, Iglesias J.
    Randomized phase II study of high-dose paclitaxel with or without amifostine in patients with metastatic breast cancer.
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  • Gennari A, Salvadori B, Donati S.
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  • Gold MA, Walker JL, Berek JS, Hallum AV 3rd, Garcia DJ, Alberts DS.
    Amifostine pretreatment for protection against topotecan-induced hematologic toxicity: results of a multicenter phase III trial in patients with advanced gynecologic malignancies.
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  • Goren MP, Anthony LP, Hande KR, Johnson DH, Brade WP, Frazier MW, Bush DA, Li JT.
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  • Hartmann JT, von Vangerow A, Fels LM, Knop S, Stolte H, Kanz L, Bokemeyer C.
    A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplantation.
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  • Hasinoff BB.
    Chemistry of dexrazoxane and analogues.
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  • Hellmann K.
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  • Hensley ML, Schuchter LM, Lindley C, Meropol NJ, Cohen GI, Broder G, Gradishar WJ, Green DM, Langdon RJ Jr, Mitchell RB, Negrin R, Szatrowski TP, Thigpen JT, Von Hoff D, Wasserman TH, Winer EP, Pfister DG.
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  • Herman EH, Ferrans VJ, Jordan W.
    Reduction of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits.
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  • Johnson PW, Muers MF, Peake MD, Poulter KM, Gurney EM, Napp VV, Hepburn PM, Brown JM.
    A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small-cell lung cancer.
    Br J Cancer 2001;84:19-24. PM:11139307
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  • Katz A, Epelman S, Anelli A.
    A prospective randomized evaluation of three schedules of mesna administration in patients receiving an ifosfamide-containing chemotherapy regimen: Sustained efficiency and simplified administration.
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  • Kemp G, Rose P, Lurain J, Berman M, Manetta A, Roullet B, Hamesley H, Belpomme D, Glick J.
    Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: Results of a randomized control trial in patients with advanced ovarian cancer.
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  • Leong SS, Tan EH, Fong KW, Wilder-Smith E, Ong YK, Tai BC, Chew L, Lim SH, Wee J, Lee KM, Foo KF, Ang P, Ang PT.
    Randomized double-blind trial of combined modality treatment with or without amifostine in unresetable stage III non-small-cell lung cancer.
    J Clin Oncol 2003;21:1767-1774. PM:12721253
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  • Liu T, Liu Y, He S, Zhang Z, Kligerman MM.
    Use of radiation with or without WR-2721 in advanced rectal cancer.
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  • Lopez M, Vici P, Di Lauro K, Conti F, Paoletti G, Ferraironi A, Sciuto R, Giannarelli D, Maini CL.
    Randomized prospective clinical trial of high-dose epirubicin and dexrazoxane in patients with advanced breast cancer and soft tissue sarcomas.
    J Clin Oncol 1998;16:86-92. PM:9440727
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  • Lorusso D, Ferrandina G, Greggi S, Gadducci A, Pignata S, Tateo S, Biamonte R, Manzione L, Di Vagno G, Ferrau‘ F, Scambia G.
    Multicenter Italian Trials in Ovarian Cancer Investigators: Phase III multicenter randomized trial of amifostine as cytoprotectant in first-line chemotherapy in ovarian cancer patients.
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  • Mace JR, Keohan ML, Bernardy H, Junge K, Niebch G, Romeis P, Thoma A, Wagner T, Mueller U, Demetri G, Baker LH.
    Crossover randomized comparison of intravenous versus intravenous/oral mesna in soft tissue sarcoma treated with high-dose ifosfamide.
    Clin Cancer Res 2003;9:5829-5834. PM:14676103
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  • McDonald S, Meyerowitz C, Smudzin T, Rubin P.
    Preliminary results of a pilot study using WR-2721 before fractionated irradiation of the head and neck to reduce salivary gland dysfunction.
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  • Ormstad K, Orrenius S, Lastbom T, Uehara N, Pohl J, Stekar J, Brock N. Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.
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  • Patt HM, Tyree EB, Straube RL.
    Cystein protection against X-irradiation.
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  • Phillips TL, Yuhas JM, Wasserman TH.
    Differential protection against alkylating agent injury in tumors and normal tissues.
    In: Annonymus (ed) Radioprotectors and Anticarcinogens.
    Academic Press 1993;735-748.


  • Poplin EA, LoRusso P, Lokich JJ, Gullo JJ, Leming PD, Schulz JJ, Veach SR, Mc Culloch W, Baker L Schein P.
    Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer.
    Cancer Chemother Pharmacol 1994;33:415-419. PM:8306416
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  • Schiller JH, Storer B, Berlin J, Wittenkeller J, Larson M, Pharo L, Berry W.
    Amifostine, cisplatin, and vinblastin in metastatic non-small-cell lung cancer: a report of high response rates and prolonged survival.
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  • Schroeder PE, Jensen PB, Sehested M, Hofland KF, Langer SW, Hasinoff BB.
    Metabolism of Dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide.
    Cancer Chemother Pharmacol 2003;52:167-174. PM:12750840
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  • Schuchter LM, Hensley ML, Meropol NJ, Winer EP.
    American Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel. 2002 update of recommendations for use of the chemotherapy and radiotherapy protectants. Clinical Practice Guidelines of the American Society of Clinical Oncology.
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  • Shaw LM, Bonner HS, Brown DQ.
    Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse.
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  • Shaw LM, Bonner H, Lieberman R.
    Pharmacokinetic profile of amifostine.
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  • Shaw LM, Bonner H, Schuchter L, Schiller JH, Nakashima H, Lieberman R.
    Population pharmacokinetics (PK) of amifostine (AMI) in cancer patients.
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  • Sparano JA, Speyer J, Gradishar WJ, Liebes L, Sridhara R, Mendoz Fry D, Egorin MJ.
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  • Speyer JL, Green MD, Kramer E, Rey M, Sanger J, Ward C, Dubin Ferrans V, Stecy P, Zeleniuch-Jacquotte A.
    Protective effect of the bisperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advance breast cancer.
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  • Vacha P, Fehlauer F, Mahlmann B, Marx M, Hinke A, Sommer K, Richter E, Feyerabend T.
    Randomized phase III trial of postoperative radiochemotherapy +/- amifostine in head and neck cancer.Is there evidence for radioprotection?
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  • Vieira MM, Brito GA, Bilarmino-Filho JN, Macedo FY, Nery KA, Cunha FQ, Ribeiro RA.
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  • Wexler LH, Andrich MP, Venzon D, Berg SL, Weaver-McClure L, Chen CC, Dilsizian V, Avila N, Jarosinski P, Balis FM, Poplack DG, Horowitz ME.
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